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4 photo(s) Updated on: 07/26/2020
  • Wright-Giemsa stain of bone marrow aspirate showing a histiocyte with an internalized granulocyte
  • Wright-Giemsa stain of bone marrow aspirate showing histiocytes with internalized erythrocyte precursors
  • H&E stain of bone marrow core biopsy showing small spherical objects (stars) with a peripheral halo in many of the histiocytes.
  • GMS stain of bone marrow core biopsy

HLH with Histoplasmosis




The patient has both Hemophagocytic lymphohistiocytosis and fungal elements compatible with Histoplasma. A positive galactomannan antigen was also found in the patient's urine, which further supported a diagnosis of disseminated histoplasmosis.  

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