Case History: 35-year-old woman with a 1.8 cm gastric mass and enlarged perigastric lymph nodes. The photomicrographs are of the perigastric lymph node (click on images for additional information). 

Which of the following statements best fits your diagnosis? 

A. This is an adenoneuroendocrine neoplasm and is, by definition, indolent in nature.

B. Since both tumor components stain with keratin AE1/AE3, this is an adenocarcinoma with neuroendocrine differentiation.

C. By arbitrary convention, each component of a mixed neuroendocrine-non-neuroendocrine neoplasm must constitute at least 30% of the neoplasm.

D. Collision tumors with independent neuroendocrine and non-neuroendocrine neoplasms are classified as adenoneuroendocrine neoplasms. 

E. This is a mixed neuroendocrine-non-neuroendocrine neoplasm, composed of neuroendocrine and glandular tumor components; presence of any other histologic variant would militate against this diagnosis.