A 64 y/o otherwise healthy male with a PSA of 15ng/ml undergoes standard 12 core prostate needle biopsy. Two of the cores reveal the following morphology. A PIN4 immunohistochemical cocktail is also shown. What is your interpretation?

A. Prostate adenocarcinoma, grade group 1 and intraductal carcinoma

B. Prostate adenocarcinoma, grade group 3 with 70% Gleason pattern 4

C. High grade prostatic intraductal neoplasia (HGPIN) with associated small acinar proliferation


Click here to view the answer

Images

4 photo(s) Updated on: 12/28/2021
  • Triple cocktail stain (red cytoplasmic - AAMCR, brown cytoplasmic- HMWK, brown nuclear - p63).

Submitting pathologist


Powered by Wild Apricot Membership Software