A 64 y/o otherwise healthy male with a PSA of 15ng/ml undergoes standard 12 core prostate needle biopsy. Two of the cores reveal the following morphology. A PIN4 immunohistochemical cocktail is also shown. What is your interpretation?

A. Prostate adenocarcinoma, grade group 1 and intraductal carcinoma

B. Prostate adenocarcinoma, grade group 3 with 70% Gleason pattern 4

C. High grade prostatic intraductal neoplasia (HGPIN) with associated small acinar proliferation


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