A 36-year-old woman with lower quadrant abdominal pain is noted to have an appendiceal mass on imaging. H&E photomicrographs are shown. What is your diagnosis? A. Well-differentiated invasive mucinous adenocarcinoma B. Low-grade appendiceal mucinous neoplasm (LAMN) C. High-grade appendiceal mucinous neoplasm (HAMN) D. Mucocele due to appendiceal adenoma E. Diverticulosis What is the most typical staining and mutational pattern in this tumor? A. CK20+, SATB2-, PAX8+ ; KRAS and/or GNAS mutated B. CK20+, SATB2+, PAX8- ; KRAS and/ or GNAS mutated C. CK7+, SATB2-, PAX8- ; KRAS and BRAF mutated D. CDX2+, SATB2-, PAX8+ ; BRAF and TP53 mutated Click here to view the answer | Images |
SUBMITTING PATHOLOGIST Maryam Zenali |