A 36-year-old woman with lower quadrant abdominal pain is noted to have an appendiceal mass on imaging. H&E photomicrographs are shown. 


What is your diagnosis?

A. Well-differentiated invasive mucinous adenocarcinoma

B. Low-grade appendiceal mucinous neoplasm (LAMN)

C. High-grade appendiceal mucinous neoplasm (HAMN)

D. Mucocele due to appendiceal adenoma

E. Diverticulosis


What is the most typical staining and mutational pattern in this tumor? 

A. CK20+, SATB2-, PAX8+ ; KRAS and/or GNAS mutated

B. CK20+, SATB2+, PAX8- ; KRAS and/ or GNAS mutated

C. CK7+, SATB2-, PAX8- ; KRAS and BRAF mutated

D. CDX2+, SATB2-, PAX8+ ; BRAF and TP53 mutated


Click here to view the answer

Images

4 photo(s) Updated on: 11/23/2022

SUBMITTING PATHOLOGIST

Maryam Zenali

Powered by Wild Apricot Membership Software